Rosa Santiago was an inmate at Prison Station 13.
With the assistance of her seven sons, she was the head of the Santiago crime family, based in the Chara system. They were rumoured to be involved in drug dealing and prostitution.
During her incarceration, she was a very influential figure inside the prison, offering protection and able to procure certain items on the black market.
She unwittingly aided Sabina White during her escape attempt, by getting her access to the laundry room.